Cassino, town, Lazio (Latium) regione, central Italy. Cassino lies along the Rapido 🍉  River at the foot of Monte (mount) Cassino, 87 miles (140 km) southeast of Rome. It originated as Casinum, a 🍉  town of the ancient Volsci people on a site adjacent to the modern town, on the lower slopes of the 🍉  mountain.